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Publications

Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells

Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells

Molecular Therapy , March 2024

Nathan Singh

Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy

Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy

Immunity, October 2023

Nathan Singh, Marcela V Maus

Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction

Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction

Blood, June 2023

Mehmet Emrah Selli, Jack H Landmann, Marina Terekhova, John Lattin, Amanda Heard, Yu-Sung Hsu, Tien-Ching Chang, Jufang Chang, John Warrington, Helen Ha, Natalie Kingston, Graham Hogg, Michael Slade, Melissa M Berrien-Elliott, Mark Foster, Samantha Kersting-Schadek, Agata Gruszczynska, David DeNardo, Todd A Fehniger, Maxim Artyomov, Nathan Singh

Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures

Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures

STAR Protocols, January 2023

Mehmet Emrah Selli, Jack H Landmann, Corvin Arveseth, Nathan Singh

Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies

Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies

Blood Advances, October 2022

Armin Ghobadi, Jack H Landmann, Alun Carter, Matthew L Cooper, Mehmet Emrah Selli, Jufang Chang, Matthew Baker, Christopher A Miller, Francesca Ferraro, David Y Chen, Amanda M Smith, Taylor A LaValle, Eric J Duncavage, Justin Chou, Victor Tam, Joseph M Benoun, Jenny Nater, Nathalie Scholler, Francesca Milletti, Remus Vezan, Adrian Bot, John M Rossi, Nathan Singh

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Nature Communications, June 2022

Amanda Heard, Jack H Landmann, Ava R Hansen, Alkmini Papadopolou, Yu-Sung Hsu, Mehmet Emrah Selli, John M Warrington, John Lattin, Jufang Chang, Helen Ha, Martina Haug-Kroeper, Balraj Doray, Saar Gill, Marco Ruella, Katharina E Hayer, Matthew D Weitzman, Abby M Green, Regina Fluhrer, Nathan Singh

Advances in CAR design

Advances in CAR design

Best Practice and Research Clinical Haematology, September 2021

Amanda Heard, Jufang Chang, John M Warrington, Nathan Singh

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

Nature Medicine, May 2021

Nathan Singh, Noelle V Frey, Boris Engels, David M Barrett, Olga Shestova, Pranali Ravikumar, Katherine D Cummins, Yong Gu Lee, Raymone Pajarillo, Inkook Chun, Amy Shyu, Steven L Highfill, Andrew Price, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xueqing Maggie Lu, David A Christian, Jessica Perazzelli, Simon F Lacey, Nathan H Roy, Janis K Burkhardt, Florent Colomb, Mohammad Damra, Mohamed Abdel-Mohsen, Ting Liu, Dongfang Liu, Daron M Standley, Regina M Young, Jennifer L Brogdon, Stephan A Grupp, Carl H June, Shannon L Maude, Saar Gill, Marco Ruella

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

Impaired Death Receptor Signaling in Leukemia Causes Antigen-Independent Resistance by Inducing CAR T-cell Dysfunction

Cancer Discovery, April 2020

Nathan Singh, Yong Lee, Olga Shestova, Pranali Ravikumar, Katharina Hayer, Seok Jae Hong, Xeuqing Maggie Lu, Raymone Pajarillo, Sangya Agarwal, Shunichiro Kuramitsu, Elena Orlando, Karen Mueller, Charly Good, Shelly Berger, Ophir Shalem, Matthew Weitzman, Noelle Frey, Shannon Maude, Stephan Grupp, Carl June, Saar Gill, Marco Ruella