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Publications

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors

Rational Protein Engineering to Enhance MHC-Independent T-cell Receptors

Cancer Discovery, November 2024

Ju-fang Chang, Jack Landmann, Tien-Ching Chang, Mehmet Selli, Yangdon Tenzin, John Warrington, Julie Ritchey, Yu-Sung Hsu, Michael Slade, Deepesh Gupta, John DiPersio, Alex Holehouse, Nathan Singh

Regulatory Considerations for Genome-Edited T-cell Therapies

Regulatory Considerations for Genome-Edited T-cell Therapies

Cancer Immunology Research , November 2024

Julie Jadlowsky, Ju-fang Chang, David Spencer, John Warrington, Bruce Levine, Carl June, Joseph Fraietta, Nathan Singh

Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors

Identification of Core Techniques That Enhance Genome Editing of Human T Cells Expressing Synthetic Antigen Receptors

Cancer Immunology Research , November 2024

Ju-fang Chang, Nils Wellhausen, Nils Engel, Jack Landmann, Caitlin Hopkins, January Salas-McKee, Adham Bear, Mehmet Selli, Sangya Agarwal, Julie Jadlowsky, Gerald Linette, Saar Gill, Carl June, Joseph Fraietta, Nathan Singh

Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells

Analysis of pre-treatment tumors reveals gatekeepers of response to CAR T cells

Molecular Therapy , March 2024

Nathan Singh

Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy

Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy

Immunity, October 2023

Nathan Singh, Marcela V Maus

Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction

Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction

Blood, June 2023

Mehmet Emrah Selli, Jack H Landmann, Marina Terekhova, John Lattin, Amanda Heard, Yu-Sung Hsu, Tien-Ching Chang, Jufang Chang, John Warrington, Helen Ha, Natalie Kingston, Graham Hogg, Michael Slade, Melissa M Berrien-Elliott, Mark Foster, Samantha Kersting-Schadek, Agata Gruszczynska, David DeNardo, Todd A Fehniger, Maxim Artyomov, Nathan Singh

Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures

Inducing T cell dysfunction by chronic stimulation of CAR-engineered T cells targeting cancer cells in suspension cultures

STAR Protocols, January 2023

Mehmet Emrah Selli, Jack H Landmann, Corvin Arveseth, Nathan Singh

Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies

Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies

Blood Advances, October 2022

Armin Ghobadi, Jack H Landmann, Alun Carter, Matthew L Cooper, Mehmet Emrah Selli, Jufang Chang, Matthew Baker, Christopher A Miller, Francesca Ferraro, David Y Chen, Amanda M Smith, Taylor A LaValle, Eric J Duncavage, Justin Chou, Victor Tam, Joseph M Benoun, Jenny Nater, Nathalie Scholler, Francesca Milletti, Remus Vezan, Adrian Bot, John M Rossi, Nathan Singh

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

Nature Communications, June 2022

Amanda Heard, Jack H Landmann, Ava R Hansen, Alkmini Papadopolou, Yu-Sung Hsu, Mehmet Emrah Selli, John M Warrington, John Lattin, Jufang Chang, Helen Ha, Martina Haug-Kroeper, Balraj Doray, Saar Gill, Marco Ruella, Katharina E Hayer, Matthew D Weitzman, Abby M Green, Regina Fluhrer, Nathan Singh

Advances in CAR design

Advances in CAR design

Best Practice and Research Clinical Haematology, September 2021

Amanda Heard, Jufang Chang, John M Warrington, Nathan Singh

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